The Analysis of Terpenes in Cannabis Matrices using Liquid Injection GC-MS Tips and Tricks

Terpenes are a class of endogenous chemicals expressed by Cannabis spp. at levels up to 1% – 2% by weight. This chemical class is typically analyzed using headspace GC methodologies. However, this approach has been shown require long incubation times in the headspace auto-sampler, and to discriminate against higher molecular weight (higher boiling) terpenes partitioning into the headspace – especially in the presence of high concentrations of cannabinoids. This presentation will demonstrate the advantages of liquid injection GC-MS over headspace methods for the analysis of terpenes in various cannabis matrices.Presenter Information: Dr. Anthony Macherone, Senior Scientist & Strategic Program Manager, Agilent Technologies, Inc.

Dr. Anthony Macherone is currently a Senior Scientist & Strategic Program Manager with Agilent Technologies, and a Visiting Professor at the Johns Hopkins University School of Medicine. He is an expert in exposomics and actively engaged in several publicly or privately funded exposomics investigations. For the past several years, Anthony has also been leading a team of Agilent applications experts for the development and deployment of analytical testing methodologies to assure quality and safety of cannabis products.